The RESPImmun Faculty

	Grażyna KWAPISZEWSKA, PhD Interplay between inflammatory cells and basement membrane components in the development of pulmonary hypertension due to chronic lung diseases
Otto Loewi Research Center, Division of Physiology; Medical University of Graz, Neue Stiftingstalstraße 6/VI; Ludwig Boltzmann Institute for Lung Vascular Rearch, Medical University of Graz, Neue Stiftingtalstraße 6/VI, A-8010 Graz; phone: +43-316-380 72918, fax: +43-316-380 72058, ✉ e-mail
websites: [RESPImmun] [LBG]
• Profile     • Curriculum vitae     • PhD students     • Grants     • Publications ⏬

List of publications:

• See ⏩ Fodok Med Uni Graz

10 most significant publications:

1. Birnhuber A, Crnkovic S, Biasin V, Marsh LM, Odler B, Sahu-Osen A, Stacher-Priehse E, Brcic L, Schneider F, Cikes N, Ghanim B, Klepetko W, Graninger W, Allanore Y, Eferl R, Olschewski A, Olschewski H, Kwapiszewska G: IL-1 receptor blockade skews inflammation towards Th2 in a mouse model of systemic sclerosis. Eur Respir J, 2019; 54(3):​1900154.
2. Marsh LM, Jandl K, Grünig G, Foris V, Bashir M, Ghanim B, Klepetko W, Olschewski H, Olschewski A, Kwapiszewska G: The inflammatory cell landscape in the lungs of patients with idiopathic pulmonary arterial hypertension. Eur Respir J, 2018; 51(1):​1701214.
3. Crnkovic S, Marsh LM, El Agha E, Voswinckel R, Ghanim B, Klepetko W, Stacher-Priehse E, Olschewski H, Bloch W, Bellusci S, Olschewski A, Kwapiszewska G: Resident cell lineages are preserved in pulmonary vascular remodeling. J Pathol, 2018; 244(4):​485–498.
4. Hoffmann J, Wilhelm J, Marsh LM, Ghanim B, Klepetko W, Kovacs G, Olschewski H, Olschewski A, Kwapiszewska G: Distinct differences in gene expression patterns in pulmonary arteries of patients with chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis with pulmonary hypertension. Am J Respir Crit Care Med, 2014; 190(1):​98–11.
5. Weisel FC, Kloepping C, Pichl A, Sydykov A, Kojonazarov B, Wilhelm J, Roth M, Ridge KM, Igarashi K, Nishimura K, Maison W, Wackendorff C, Klepetko W, Jaksch P, Ghofrani HA, Grimminger F, Seeger W, Schermuly RT, Weissmann N, Kwapiszewska G: Impact of S-Adenosylmethionine Decarboxylase 1 in Pulmonary Vascular Remodeling. Circulation, 2014; 129(14):​1510–1523.
6. Kwapiszewska G, Markart P, Dahal BK, Kojonazarov B, Marsh LM, Schermuly RT, Taube C, Meinhardt A, Ghofrani HA, Steinhoff M, Seeger W, Preissner KT, Olschewski A, Weissmann N, Wygrecka M: PAR-2 inhibition reverses experimental pulmonary hypertension. Circulation, 2012; 110(9):​1179–1181.
7. Kwapiszewska G, Chwalek K, Marsh LM, Wygrecka M, Wilhelm J, Best J, Egemnazarov B, Weisel FC, Osswald SL, Schermuly RT, Olschewski A, Seeger W, Weissmann N, Eickelberg O, Fink L: BDNF/TrkB signaling augments smooth muscle cell proliferation in pulmonary hypertension. Am J Pathol, 2012; 181(6):​2018–2029.
8. Seimetz M, Parajuli N, Pichl A, Veit F, Kwapiszewska G, Weisel FC, Milger K, Egemnazarov B, Turowska A, Fuchs B, Nikam S, Roth M, Sydykov A, Medebach T, Klepetko W, Jaksch P, Dumitrascu R, Garn H, Voswinckel R, Kostin S, Seeger W, Schermuly RT, Grimminger F, Ghofrani HA, Weissmann N: Inducible NOS inhibition reverses tobacco-smoke-induced emphysema and pulmonary hypertension in mice. Cell, 2011; 147(2):​293–305.
9. Kwapiszewska G, Wygrecka M, Marsh LM, Schmitt S, Trösser R, Wilhelm J, Helmus K, Eul B, Zakrzewicz A, Ghofrani HA, Schermuly RT, Bohle RM, Grimminger F, Seeger W, Eickelberg O, Fink L, Weissmann N: Fhl-1, a new key protein in pulmonary hypertension. Circulation, 2008; 118(11):​1183–1194.
10. Mittal M, Roth M, König P, Hofmann S, Dony E, Goyal P, Selbitz AC, Schermuly RT, Ghofrani HA, Kwapiszewska G, Kummer W, Klepetko W, Hoda MA, Fink L, Hänze J, Seeger W, Grimminger F, Schmidt HH, Weissmann N: Hypoxia-dependent regulation of nonphagocytic NADPH oxidase subunit NOX4 in the pulmonary vasculature. Ciirculation, 2007; 101(3):​258–267.

30.07.2020 RESPImmun · Doctoral Programme “Immune Modulation in Respiratory Diseases”