The RESPImmun Faculty

	Ákos HEINEMANN, MD Short chain fatty acids and pulmonary endothelial function
Otto Loewi Research Centre, Division of Pharmacology, Medical University of Graz, Neue Stiftingtalstraße 6, A-8010 Graz; phone: +43-316-385 74112, fax: +43-316-385 79613, ✉ e-mail
websites: [RESPImmun] [DK-MOLIN] [MOLMED]
• Profile     • Curriculum vitae     • PhD students     • Grants     • Publications ⏬

List of publications:

• See ⏩ Fodok Med Uni Graz

10 most significant publications:

1. Abdellatif M, Trummer-Herbst V, Koser F, Durand S, Adão R, Vasques-Nóvoa F, Freundt JK, Voglhuber J, Pricolo MR, Kasa M, Türk C, Aprahamian F, Herrero-Galán E, Hofer SJ, Pendl T, Rech L, Kargl J, Anto-Michel N, Ljubojevic-Holzer S, Schipke J, Brandenberger C, Auer M, Schreiber R, Koyani CN, Heinemann A, Zirlik A, Schmidt A, von Lewinski D, Scherr D, Rainer PP, von Maltzahn J, Mühlfeld C, Krüger M, Frank S, Madeo F, Eisenberg T, Prokesch A, Leite-Moreira AF, Lourenço AP, Alegre-Cebollada J, Kiechl S, Linke WA, Kroemer G, Sedej S: Nicotinamide for the treatment of heart failure with preserved ejection fraction. Sci Transl Med, 2021; 13(580):eabd7064.
2. Pfeil EM, Brands J, Merten N, Vögtle T, Vescovo M, Rick U, Albrecht IM, Heycke N, Kawakami K, Ono Y, Ngako Kadji FM, Hiratsuka S, Aoki J, Häberlein F, Matthey M, Garg J, Hennen S, Jobin ML, Seier K, Calebiro D, Pfeifer A, Heinemann A, Wenzel D, König GM, Nieswandt B, Fleischmann BK, Inoue A, Simon K, Kostenis E: Heterotrimeric G Protein Subunit Gaq Is a Master Switch for Gß?-Mediated Calcium Mobilization by Gi-Coupled GPCRs. Mol Cell, 2020; 80(6):​940–954.e6.
3. Bärnthaler T, Theiler A, Zabini D, Trautmann S, Stacher-Priehse E, Lanz I, Klepetko W, Sinn K, Flick H, Scheidl S, Thomas D, Olschewski H, Kwapiszewska G, Schuligoi R, Heinemann A: Inhibiting eicosanoid degradation exerts antifibrotic effects in a pulmonary fibrosis mouse model and human tissue. J Allergy Clin Immunol, 2020; 145(3):​818–833.e11.
4. Theiler A, Bärnthaler T, Platzer W, Richtig G, Peinhaupt M, Rittchen S, Kargl J, Ulven T, Marsh LM, Marsche G, Schuligoi R, Böhm EM, Heinemann A: Butyrate ameliorates allergic airway inflammation by limiting eosinophil trafficking and survival. J Allergy Clin Immunol, 2019; 144(3):​764–776.
5. Bärnthaler T, Jandl K, Sill H, Uhl B, Schreiber Y, Grill M, Thomas D, Schicho R, Marsche G, Frank S, Heinemann A, Schuligoi R: Imatinib stimulates prostaglandin E₂ and attenuates cytokine release via EP4 receptor activation. J Allergy Clin Immunol, 2019; 143(2):​794–797.e10.
6. Maric J, Ravindran A, Mazzurana L, Van Acker A, Rao A, Kokkinou E, Ekoff M, Thomas D, Fauland A, Nilsson G, Wheelock CE, Dahlén SE, Ferreirós N, Geisslinger G, Friberg D, Heinemann A, Konya V, Mjösberg J: Cytokine-induced endogenous production of prostaglandin D2 is essential for human group 2 innate lymphoid cell activation. J Allergy Clin Immunol, 2019; 143(6):​2202–2014.
7. Jandl K, Stacher E, Bálint Z, Böhm EM, Maric J, Peinhaupt M, Luschnig P, Aringer I, Fauland A, Konya V, Dahlen SE, Wheelock CE, Kratky D, Olschewski A, Marsche G, Schuligoi R, Heinemann A: Activated prostaglandin D₂ receptors on macrophages enhance neutrophil recruitment into the lung. J Allergy Clin Immunol, 2016; 137(3):​833–843.
8. Konya V, Üllen A, Kampitsch N, Theiler A, Philipose S, Parzmair GP, Marsche G, Peskar BA, Schuligoi R, Sattler W, Heinemann A: Endothelial E-type prostanoid 4 receptors promote barrier function and inhibit neutrophil trafficking. J Allergy Clin Immunol, 2013; 131(2):​532–540.e1-2.
9. Blättermann S, Peters L, Ottersbach PA, Bock A, Konya V, Weaver CD, Gonzalez A, Schröder R, Tyagi R, Luschnig P, Gäb J, Hennen S, Ulven T, Pardo L, Mohr K, Gütschow M, Heinemann A, Kostenis E: A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer. Nat Chem  Biol, 2012; 8(7):​631–638.
10. Konya V, Böhm EM, Schratl P, Beubler E, Marsche G, Schuligoi R, Lippe IT, Peskar BA, Heinemann A: Endothelium-derived prostaglandin I₂ controls the migration of eosinophils. J Allergy Clin Immunol, 2010; 125(5):​1105–1113.

31.08.2021 RESPImmun · Doctoral Programme “Immune Modulation in Respiratory Diseases”